Protein Details: ATP-sensitive inward rectifier potassium channel 15
Protein ID
ICDB_Pro_0247
Protein Name
ATP-sensitive inward rectifier potassium channel 15
Gene Name
KCNJ15
Organism
Cavia porcellus (Guinea pig)
Length
375 amino acids
AlphaFoldDB
AF-O70339-F1-model_v4.pdb
Function
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised; the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity)
Sequence
MDTIHMSVTRPPPEKHMAGPGLKTHRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPSEAISNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSSDCTFYCADSEKQKLEEKYRQEDQRERELRTLLLHQSNV
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1074/jbc.273.37.23884
RefSeq
XP_013001561.1; XP_013001562.1; XP_013001563.1; XP_013001564.1; XP_013001565.1; XP_013001566.1; XP_013001567.1; XP_013001568.1